The allergenicity of a wide range of house dust mite antigens
Based upon research describing the immunobiological profiles and potential allergenicity of antigens from house dust mites* this paper demonstrates how major and mid-range mite antigens can trigger a wide range of antibodies in the human immune response.
The responses range from excessive immediate IgE allergic reactions associated with acute childhood asthma to IgG4 allergic responses in adults and children.
‘IgE and IgG antihouse dust mite specificities in allergic disease’ Hales BJ, Martin AC, Pearce LJ, Laing IA, Hayden CM, Goldblatt J, Le Souef PN, Thomas WR. 2002 J Allergy and Clinical Immunology, 22 May online. (in press) doi:10.1016/j.jaci.2006.04.001
*Characterization and Immunobiology of House Dust Mite Allergens, Thomas WR, Smith WA, Hales BJ, Mills KL, O’Brien RM, Int Arch Allergy Immunol, 2002, 129:1-18
